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RESEARCH ARTICLE
Year : 2016  |  Volume : 4  |  Issue : 1  |  Page : 4

Evaluation of tricuspid regurgitant jet velocity in thalassemia patients with splenectomy


1 Assistant Professor of Cardiology, Fellow of Echocardiography, Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran
2 Assistant Professor of Cardiology, Fellow of Echocardiography, Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
3 Assistant Professor of Pulmonology, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran
4 General Physician, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran
5 Fellow of Echocardiography, Rasul Akram General Hospital, Iran University of Medical Sciences, Tehran, IR Iran

Correspondence Address:
Nehzat Akiash
Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
IR Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.5812/acvi.39394

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Background: β-thalassemia is an inherited disorder of β-globin biosynthesis. Dysfunction in hemoglobin chain production, ineffective erythropoiesis, and hemolysis occur in β-thalassemia. Pulmonary arterial hypertension (PAH) is increasingly detected in patients with β-thalassemia, and splenectomy which decreases the need for blood transfusion increases the pulmonary artery pressure (PAP). Objectives: This study aimed to assess the PAP in patients with β-thalassemia (male or female and major or intermedia) who had undergone splenectomy. Methods: A total of 137 patients suffering from β-thalassemia were evaluated during the study. All subjects were referred for cardiac evaluation. Clinical history, presence of cardiac symptoms, and previous splenectomy were noted. Standard M-mode, 2D, and Doppler echocardiographic examinations were performed for all subjects. Patients with a tricuspid regurgitant jet velocity (TRV) ≥2.5 m/s were considered at risk for PAH. Results: Average age of the patients was 21.15±6.68 years. No significant difference was observed in the PAP between the 2 groups of thalassemia major and intermedia and also the 2 sex groups. Indeed, 6.6% of the patients had an increased PAP. The significant finding of the study was that the patients who had had splenectomy were significantly at an increased risk of PAH (P = 0.046). Conclusions: The etiology of PAH in thalassemia is multifactorial such as inflammatory mediators. Also, the absence of the spleen plays an important role in developing a high TRV and PAH.


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